Phosphate-binding polymers for oral administration
AssigneeGenzyme Corporation
InventorsStephen Randall Holmes-Farley, W. Harry Mandeville, III, George M. Whitesides
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Abstract
Phosphate-binding polymers are provided for removing phosphate from the gastrointestinal tract. The polymers are orally administered, and are useful for the treatment of hyperphosphatemia.
Claims20
A method for removing phosphate from a patient in need thereof comprising orally administering to said patient a therapeutically effective amount of a pharmaceutical composition comprising a crosslinked, water insoluble polyallylamine copolymer wherein said crosslinked, water insoluble polyallylamine copolymer consists of a crosslinking agent and repeat units represented by the following structural formulae:
- wherein n is an integer, and X− represents a negatively charged counterion.
A method of decreasing the serum phosphate level of a patient in need thereof comprising orally administering to said patient a therapeutically effective amount of a pharmaceutical composition comprising a crosslinked, water insoluble polyallylamine copolymer wherein said crosslinked, water insoluble polyallylamine copolymer consists of a crosslinking agent and repeat units represented by the following structural formulae:
- wherein n is an integer, and X− represents a negatively charged counterion.
Dependencies are inferred from the claim text.