Stabilized aerosol dispersions
Assignee3M Innovative Properties Company
InventorsJimmie R. Baran, Jr., Brian J. Gabrio, James S. Stefely, Stephen W. Stein, Thomas E. Wood
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Abstract
The invention relates to stabilized dispersions containing nanoparticles of use for the administration of medicaments. The dispersions comprise excipient nanoparticles, a dispersed phase comprising medicament and a continuous phase comprising propellant.
Claims21
A stable pharmaceutical dispersion comprising:
- a dispersed solid phase comprising a medicament;
- and
- a continuous liquid phase comprising propellant and excipient nanoparticles having an average particle diameter of less than 100 nm, wherein said excipient nanoparticles are present in the dispersion in an amount from 0.001 to less than 0.5 percent by weight, wherein the dispersion does not flocculate when left undisturbed for more than 30 seconds after being shaken for 30 seconds, and
- wherein the excipient nanoparticles are surface-modified and do not comprise a medicament.
A method of stabilizing a pharmaceutical dispersion comprising the step of adding an effective amount of excipient nanoparticles to a dispersion comprising a dispersed solid phase comprising a medicament and a continuous liquid phase comprising propellant, wherein the dispersion does not flocculate when left undisturbed for more then 30 seconds after being shaken for 30 seconds, and wherein the excipient nanoparticles are surface-modified and do not comprise a medicament.
Dependencies are inferred from the claim text.