Technetium-99m-labeled organic germanium nanocolloids, method of preparing the same and use thereof
AssigneeKorea Atomic Energy Research Institute
InventorsSang Hyun Park, Hui Jeong Gwon, Myung Woo Byun
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Abstract
Disclosed relates to organic germanium nanocolloids, to which technetium-99m (99mTc), a radionuclide, is labeled, method of the same, and a spleen-imaging agent including the same. According to the invention, 99mTc-labeled organic germanium nanocolloids having high labeling efficiency and stability can be provided. Moreover, since the 99mTc-labeled organic germanium nanocolloids of the invention are accumulated in the spleen considerably higher than the conventional spleen-imaging agent, it is possible to use the 99mTc-labeled organic germanium nanocolloids of the present invention as a therapeutic radiopharmaceutical for the spleen imaging.
Claims7
A method of preparing a 99mTc-labeled organic germanium nanocolloid, comprising the steps of:
- (i) preparing an organic germanium colloidal solution by dispersing an organic germanium compound in an aqueous solvent;
- (ii) preparing a solution containing sodium pertechnetate and stannous chloride by dissolving sodium pertechnetate and stannous chloride in an acidic solvent;
- and
- (iii) adding the solution containing sodium pertechnetate and stannous chloride drop wise to the organic germanium colloidal solution to form a 99mTc-labeled organic germanium nanocolloid, wherein the 99mTc-labeled organic germanium nanocolloid has Chemcial Formula 1:
- wherein L is selected from the group consisting of bis-carboxyethylgermanium sesquioxide, spirogermanium and lactate-citrate-germanate.
A salt form of 99mTc-bis-carboxyethylgermanium sesquioxide nanocolloid of Chemical Formula 3:
A spleen-imaging agent comprising a 99mTc-labeled organic germanium nanocolloid of Chemical Formula 1:
- wherein L is selected from the group consisting of bis-carboxyethylgermanium sesquioxide, spirogermanium and lactate-citrate-germanate.
Dependencies are inferred from the claim text.