Injectable calcium phosphate cement
AssigneeHowmedica Leibinger Inc.
InventorsGerard M. Insley, Adrian Sun Wai, Donal O'Mahony, Paul Higham
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Abstract
A calcium phosphate composition comprising at least one calcium phosphate mineral, at least one reaction retarding agent, at least one biding agent, and at least one sodium phosphate compound.
Claims48
A calcium phosphate composition comprising:
- (1) at least two calcium phosphate minerals,
- (2) at least one reaction retarding agent,
- (3) at least one binding agent,
- (4) at least one sodium phosphate,
- wherein one of said at least two calcium phosphate minerals contains a stabilizing agent.
A calcium phosphate composition that is prepared by a process including the steps of:
- (a) providing at least two calcium phosphate minerals, at least one reaction retarding agent, at least one binding agent, and at least one sodium phosphate compound, and
- (b) mixing said at least two calcium phosphate minerals, said at least one reaction retarding agent, said at least one binding agent, and said at least one sodium phosphate compound in a solvent, wherein one of said at least two calcium phosphate minerals is a stabilized calcium phosphate mineral containing a stabilizing agent.
A calcium phosphate composition comprising:
- (a) a powder component comprising
- 1. at least one calcium phosphate mineral, and
- 2. a reaction retarding agent, and
- (b) a liquid component comprising
- 1. at least one binding agent,
- 2. at least one sodium phosphate compound, and
- 3. a solvent.
A kit for forming a calcium phosphate bone cement comprising:
- (a) a first container comprising a powder mixture of stabilized di-calcium phosphate dihydrate containing from about 10 ppm to about 60 ppm of magnesium, a second calcium phosphate mineral, and at least one reaction retarding agent, and
- (b) a second container comprising a solvent comprising at least one binding agent, and at least one sodium phosphate compound.
A method for making a calcium phosphate bone cement comprising:
- (a) preparing a powder component containing at least one calcium phosphate mineral, and a reaction retarding agent, and
- (b) preparing a liquid component by dissolving at least one binding agent and at least one sodium phosphate compound in a solvent, and
- (c) mixing said powder component with said liquid component.
A calcium phosphate composition comprising:
- (a) at least one calcium phosphate mineral,
- (b) at least one binding agent,
- (c) at least one sodium phosphate, and
- (d) trisodium citrate.
A calcium phosphate composition comprising:
- (a) at least one calcium phosphate mineral,
- (b) at least one reaction retarding agent,
- (c) at least one sodium phosphate, and
- (d) polyvinyl pyrrolidone.
A calcium phosphate composition comprising:
- (a) at least one calcium phosphate mineral,
- (b) at least one binding agent,
- (c) at least one reaction retarding agent, and
- (d) at least two sodium phosphate compounds.
A calcium phosphate composition comprising:
- (a) at least one calcium phosphate mineral,
- (b) at least one binding agent,
- (c) at least one sodium phosphate, and
- (d) at least one reaction retarding agent having a particle size between about 1-1000 μm.
A calcium phosphate composition comprising:
- (a) at least one calcium phosphate mineral,
- (b) at least one reaction retarding agent,
- (c) at least one binding agent, and
- (d) at least one sodium phosphate having a particle size between about 1-2500 μm.
Dependencies are inferred from the claim text.