Back to results
US 7,456,265 B2Granted
Carboxylated polysaccharides and method of preparation and use
AssigneeBoard of Trustees of Michigan State University
InventorsRamani Narayan, Laura M. Fisher
Life of this patent
Estimating the term…
Abstract
Chemically modified dicarboxy polysaccharides are described. The modified polysaccharides are useful as a carrier for cosmetics, pharmaceuticals, veterinary products and the like. The modified polysaccharides can provide a timed release of active ingredients.
Claims6
A chemically modified polysaccharide (CMP) comprising:
- a random copolymer comprising:
- (a) starch-derived or cellulose-derived saccharide rings having C2 and C3 carbon positions and a bond therebetween, the saccharide rings being linked with
- (b) ring-opened starch-derived or cellulose-derived saccharide units at the bond between the C2 and C3 carbon positions;
- wherein:
- (i) at least some of the ring-opened C2 and C3 carbon positions are carboxylic acid moieties, water dispersible salts thereof, or combinations thereof directly attached thereto;
- (ii) at least some of the ring-opened C2 and C3 carbon positions contain hydroxyl groups;
- and,
- (iii) the CMP is water dispersible to form a clear solution.
5 more elements
A pharmaceutical composition which comprises:
- (a) a medicament;
- and
- (b) a chemically modified polysaccharide (CMP) comprising a random copolymer comprising:
- starch-derived or cellulose-derived sacccharide rings having C2 and C3 carbon positions and a bond therebetween, the saccharide rings being linked with ring-opened starch-derived or cellulose-derived saccharide units at the bond between the C2 and C3 carbon positions, wherein:
- (i) at least some of the ring-opened C2 and C3 carbon positions contain carboxylic acid moieties, water dispersible salts thereof, or combinations thereof;
- (ii) at least some of the ring-opened C2 and C3 carbon positions contain hydroxyl groups;
- and
- (iii) the CMP is water dispersible to form a clear solution as a time-release adjuvant for the medicament.
5 more elements
A chemically modified polysaccharide (CMP) comprising:
- a random copolymer comprising:
- (a) saccharide rings having C2 and C3 carbon positions and a bond therebetween, the saccharide rings being linked with
- (b) ring-opened saccharide units at the bond between the C2 and C3 carbon positions;
- wherein:
- (i) the saccharide rings are represented by Formula I;
- (ii) the ring-opened saccharide units are represented by Formula II;
- (iii) R1 is H or —COOR where R is alkyl or aryl;
- (iv) C(2) and C(3) are independently selected from the group consisting of —CH2OH, —COOH, water-dispersible salts thereof, and combinations thereof;
- (v) at least some of C(2), C(3), or combinations thereof are —COOH, water-dispersible salts thereof, or combinations thereof;
- (vi) at least some of C(2) , C(3), or combinations thereof are —CH2OH;
- and,
- (vii) the CMP is water dispersible to form a clear solution.
9 more elements
A chemically modified polysaccharide (CMP) comprising:
- a random copolymer comprising:
- (a) saccharide rings having C2 and C3 carbon positions and a bond therebetween, the saccharide rings being linked with
- (b) ring-opened saccharide units at the band between the C2 and C3 carbon positions;
- wherein:
- (i) the CMP is represented by Formula III;
- (ii) the mole fraction Y of ring-opened saccharide units in the random copolymer ranges from 0.1 to 0.9;
- (iii) R1 is H or —COOR where R is alkyl or aryl;
- (iv) C(2) and C(3) are independently selected from the group consisting of —CH2OH, —COOR2, and combinations thereof, where R2 is H, an alkyl or an aryl group containing 1 to 12 carbon atoms;
- (v) at least some of C(2), C(3) or combinations thereof are —COOR2;
- (vi) at least some of C(2), C(3), or combinations thereof are —CH2OH;
- and,
- (vii) the CMP is water dispersible to form a clear solution.
9 more elements
Dependencies are inferred from the claim text.