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AssigneeMedarex, Inc.
InventorsTibor Keler, Israel Lowy, Laura A. Vitale, Diann Blanset, Mohan Srinivasan
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Isolated human monoclonal antibodies which bind to Anthrax protective antigen are disclosed. The human antibodies can be produced in a non-human transgenic animal, e.g., a transgenic mouse, capable of producing multiple isotypes of human monoclonal antibodies by undergoing V-D-J recombination and isotype switching. Also disclosed are derivatives of the human antibodies (e.g., bispecific antibodies and immunoconjugates), pharmaceutical compositions comprising the human antibodies, non-human transgenic animals and hybridomas which produce the human antibodies, and therapeutic and diagnostic methods for using the human antibodies.
An isolated monoclonal antibody comprising a heavy chain variable region comprising the amino acid sequence set forth in SEQ ID NO:2, wherein the antibody specifically binds to human B. anthracis protective antigen.
An isolated monoclonal antibody comprising a light chain variable region comprising the amino acid sequence set forth in SEQ ID NO:4, wherein the antibody specifically binds to B. anthracis protective antigen.
An isolated monoclonal antibody or antigen binding portion thereof comprising:
An isolated monoclonal antibody or antigen binding portion thereof, comprising a heavy chain variable region and a light chain variable region, wherein the sequences of the heavy chain variable region and the light chain variable region, respectively, comprise the sequences of SEQ ID NOs:
Dependencies are inferred from the claim text.