Cycloalkyl substituted polyamines for cancer therapy and methods of synthesis therefor
AssigneeProgen Pharmaceuticals Limited
InventorsAldonia L. Valasinas, Andrei V. Blokhin, Aparajita Sarkar, Hirak S. Basu, Venodhar K. Reddy, Laurence J. Marton, Yu Wang
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Abstract
Conformationally restricted polyamine compounds useful in treatment of cancer and other diseases marked by abnormal cell proliferation are disclosed. Improved methods of synthesizing such compounds are also disclosed. In one method of the invention, a carbene-bearing or carbene equivalent-bearing compound is reacted with the double bond of an alkene compound to form a cyclopropyl ring as the first step in the synthesis.
Claims14
A compound selected from the group consisting of:
- and all salts and stereoisomers thereof.
A composition comprising one or more compounds of the formula:
- or a salt or stereoisomer thereof,
- and a pharmaceutically acceptable carrier.
A method of retarding the progression of uncontrolled cell proliferation or of symptoms of uncontrolled cell proliferation, comprising administering a therapeutically effective amount of one or more compounds of the formula:
- or a salt or stereoisomer thereof.
Dependencies are inferred from the claim text.