Inositol derivatives for increasing chloride secretion and inhibiting inflammation
AssigneeInologic, Inc.
InventorsAlexis Traynor-Kaplan, Carsten Schultz, Tanja Meyerdierks, Mark Moody, Andrew Schnaars, Jane Smith
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Abstract
Inositol derivatives, compositions comprising inositol derivatives, and methods for using compositions comprising inositol derivatives as agents for activating the secretion of chloride ions and/or treatment of inflammation are described.
Claims3
A compound selected from the group consisting of 2-O-butyryl-2-C-propyl-3-O-propyl-myo-inositol 1,4,5,6-tetrakisphosphate;
- 2-O-butyryl-2-C-propyl-1-O-propyl-myo-inositol 3,4,5,6-tetrakisphosphate;
- 2,3-O-isopropylidene- 2-C-propyl-myo-inositol 1,4,5,6-tetrakisphosphate;
- 1,2-O-isopropylidene-2-C-propyl myo-inositol 3,4,5,6-tetrakisphosphate, 2-O-butyryl-1-O-octyl-myo-inositol 3,4,5,6-tetrakis- phosphate or a racemate, stereoisomer, ester or pharmaceutically acceptable salt thereof.
A method for regulating chloride secretion and/or inhibiting inflammation in a cell or tissue, comprising contacting the cell or tissue with an effective amount of a compound selected from the group consisting of 2-O-butyryl-2-C-propyl- 3-O-propylmyo-inositol 1,4,5,6-tetrakisphosphate;
- 2-O-butyryl -2-C-propyl 1-O-propyl rnyo-inositol 3,4,5,6-tetrakisphosphate;
- 2,3-O-isopropylidene2-C-propyl-myo-inositol 1,4,5,6-tetrakisphosphate;
- 1,2-O-isopropylidene-2-C-propyl-myo-inositol 3,4,5,6-tetrakis- phosphate, 2-O-butyryl-1-O-octyl-myo-inositol 3,4,5,6-tetrakisphosphate or a racemate, stereoisomer, ester or pharmaceutically acceptable salt thereof.
A method of regulating chloride secretion and/or inhibiting inflammation in a human or animal patient in need thereof comprising administering to the patient a therapeutically effective amount of a compound selected from the group consisting of 2-O-butyryl-2-C-propyl3-O-propylmyo-inositol 1,4,5,6-tetrakisphosphate;2-O-butyryl-2-C-propyl 1 O-propyl-myo-inositol 3,4,5 ,6-tetra- kisphosphate;
- 2,3 -O-isopropylidene2-C-propyl-myo-inositol 1,4,5 ,6-tetrakisphosphate;
- 1,2-O-isopropylidene-2-C-propyl-myo-inositol 3,4,5,6-tetrakisphosphate, 2-O-butyryl-1-0-octyl- myo-inositol 3,4,5,6-tetrakisphosphate or a racemate, stereoisomer, ester or pharmaceutically acceptable salt thereof.
Dependencies are inferred from the claim text.