Tetrahydro-indazole cannabinoid modulators

A compound having a structure according to formula I:

• wherein
• X1 is absent, or is lower alkylene;
• R1 is selected from the group consisting of aryl, C3-C12 cycloalkyl, or heterocyclyl, any of which are optionally substituted at one or more positions by halogen, lower alkyl, hydroxy or lower alkoxy;
• R4 is CH-aryl wherein aryl is optionally substituted at one or more positions by hydroxy, lower alkyl, lower alkoxy or halogen;
• or CH-heterocyclyl wherein heterocyclyl is optionally substituted at one or more positions by hydroxy, lower alkyl, lower alkoxy or halogen;
• R6 is absent;
• R6a is hydrogen;
• lower alkyl;
• or aryl optionally substituted by one or more of halogen, hydroxy, lower alkoxy, carboxy or alkoxycarbonyl;
• R9 is aryl optionally substituted by one or more hydroxy, halogen, —NH(R6a), —SO2—NH(R6a), lower alkyl, carboxy, alkoxycarbonyl, lower alkoxy, hydroxy-alkylene-, aryloxy or arylalkoxy;
• C3-C12 cycloalkyl optionally substituted by one or more hydroxy, halogen, amino, lower alkyl, carboxy, alkoxycarbonyl, lower alkoxy, hydroxy-alkylene-, aryloxy, arylalkoxy, or lower alkylene;
• or heterocyclyl optionally substituted by one or more hydroxy, halogen, amino, lower alkyl, carboxy, alkoxycarbonyl, lower alkoxy, hydroxy-alkylene-, aryloxy or arylalkoxy
• R9a is hydrogen or lower alkyl;
• Z2 is absent;
• or is lower alkylene optionally substituted at one or more positions by aryl, cycloalkyl, halogen, hydroxy, lower alkyl, lower alkoxy, carboxy, alkoxycarbonyl or aryl;
• or a pharmaceutically acceptable salt or polymorph thereof.