Substituted quinoline derivatives

A compound of formula I:

• wherein:
• m is an integer from 0 to 3;
• R1 is selected from the group consisting of acylamino, carboxyl ester, and C1 to C5 alkyl optionally substituted with hydroxy, or halo;
• R2 is hydrogen or C1 to C5 alkyl;
• R3 is —C(═X)-A, wherein A is selected from the group consisting of aryl, heteroaryl, heterocyclic, and cycloalkyl, all of which may be optionally substituted with 1 to 4 substituents selected from the group consisting of C1 to C4 alkyl, C1 to C4 alkoxy, halo, hydroxy, and nitro and X is oxygen or sulfur;
• R4 is -alkylene-heterocyclic or -alkylene-NR7R8 wherein alkylene is a C1 to C4 straight chained alkylene;
• R7 and R8 are independently selected from the group consisting of hydrogen, C1 to C4 alkyl, arylalkyl, heteroarylalkyl, cycloalkyl and cycloalkylalkyl;
• R5 is selected from the group consisting of L-A1, wherein A1 is selected from the group consisting of aryl, heteroaryl, heterocyclic, and cycloalkyl, all of which may be optionally substituted with 1 to 4 substituents selected from the group consisting of C1 to C4 alkyl, C1 to C4 alkoxy, halo, hydroxy, and nitro and wherein L is selected from the group consisting of oxygen, —NR9 where R9 is hydrogen or alkyl, —S(O)q— where q is zero, one or two, and C1 to C5 alkylene, optionally substituted with hydroxy, halo, or acylamino;
• and
• R6 is selected from the group consisting of C1 to C5 alkyl, C2 to C5 alkenyl, C2 to C5 alkynyl, —CF3, C1 to C5 alkoxy, halo, and hydroxy;
• or a pharmaceutically acceptable salt thereof.