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US 7,452,995 B2Granted
Aryl aniline β2 adrenergic receptor agonists
AssigneeTheravance, Inc.
InventorsEdmund J. Moran, John R. Jacobsen, James Aggen
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Abstract
The invention provides novel β2 adrenergic receptor agonist compounds. The invention also provides pharmaceutical compositions comprising such compounds, methods of using such compounds to treat diseases associated with β2 adrenergic receptor activity, and processes and intermediates useful for preparing such compounds.
Claims12
A compound of formula (V):
- wherein:
- R1 is methoxy or ethoxy, and R2 is hydrogen or phenyl;
- or R1 is hydrogen, and R2 is phenyl;
- R3 is —CH2OH or —NHCHO, and R4 is hydrogen;
- or R3 and R4 taken together are —NHC(═O)CH═CH—;
- Ra is hydrogen or an amino-protecting group;
- and
- Rb is a hydroxy-protecting group.
5 more elements
Dependencies are inferred from the claim text.