Interfering RNA molecules
AssigneeSilence Therapeutics GmbH
InventorsKlaus Giese, Jörg Kaufmann, Anke Klippel-Giese
Life of this patent
Estimating the term…
Abstract
The present invention is related to a ribonucleic acid comprising a double stranded structure whereby the double-stranded structure comprises a first strand and a second strand, whereby the first strand comprises a first stretch of contiguous nucleotides and whereby said first stretch is at least partially complementary to a target nucleic acid, and the second strand comprises a second stretch of contiguous nucleotides whereby said second stretch is at least partially identical to a target nucleic acid, and whereby the double stranded structure is blunt ended.
Claims7
A nucleic acid molecule comprising a first strand and a second strand,
- wherein said first strand comprises a first stretch that is complementary to a target nucleic acid,
- wherein said second strand comprises a second stretch that is the same length as said first stretch and that is complementary to said first stretch,
- wherein said first strand and said second strand form a double-stranded structure consisting of said first stretch and said second stretch,
- wherein said first stretch and said second stretch each consist of contiguous alternating single 2′-O-methyl modified and single unmodified ribonucleotides,
- wherein said 2′-O-methyl modified and unmodified ribonucleotides in each stretch are linked by phosphodiester bonds,
- wherein each modified ribonucleotide in said first stretch is base paired with a said unmodified ribonucleotide in said second stretch,
- wherein each modified ribonucleotide in said second stretch is base paired with a said unmodified ribonucleotide in said first stretch, and
- wherein each stretch consists of 15-23 ribonucleotides.
Dependencies are inferred from the claim text.