Immunogenic complex
AssigneeArexis AB
InventorsNils Lycke, Kristian Dalsgaard, Allan Mc Mowat, Bjorn Lowenadler, Peter Kaastrup
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Abstract
The invention relates to an immunogenic complex comprising at a least one glycoside and at least one lipid, integrated into an iscom complex or matrix, and at least one antigen which antigen is integrated into the iscom complex or coupled on to or mixed with the iscom complex or iscom matrix complex, characterised in that it also comprises at least one enzyme. It also relates to such a complex further comprising at least one peptide which specifically binds to a receptor expressed on a cell capable of antigen presentation, which cell expresses MHC Class I or Class II and to compositions comprising the complexes.
Claims13
An immunogenic complex comprising:
- at least one glycoside and at least one lipid, integrated into an iscom complex or matrix;
- at least one antigen integrated into the iscom complex or coupled onto or mixed with the iscom complex or iscom matrix complex;
- and
- an adjuvant comprising
- (i) an isolated subunit of an A1 subunit of a bacterial enterotoxin selected from the group consisting of cholera toxin and E. coli heat labile enterotoxin, and
- (ii) a fragment of protein A comprising the D region of protein A, said fragment having the ability to bind to Ig or Fc receptors on an antigen-presenting cell.
Dependencies are inferred from the claim text.