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US 7,452,981 B2Granted
Humanized anti-CD4 antibody with immunosuppressive properties
AssigneeBiotest AG
InventorsJohn Wijdenes, Helmut Jonuleit
Life of this patent
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Abstract
A humanized antibody derived from mouse monoclonal anti-CD4 antibody B-F5 is able to activate CD25+CD4+ regulatory T cells and is useful for preparing immunosuppressive compositions.
Claims4
A humanized hB-F5 antibody derived from mouse monoclonal anti-CD4 antibody B-F5, wherein said hB-F5 antibody comprises V domains comprising:
- a) an H chain V domain comprising the sequence, EEQLVESGGGLVKPGGSLRLSCAASGFSFSDCRMYWLRQAPGKGLEWIGVISVK SENYGANYAESVRGRFTISRDDSKNTVYLQMNSLKTEDTAVYYCSASYYRYDV GAWFAYWGQGTLVTVSS (SEQ ID NO:
- 1);
- and
- b) a L chain V domain comprising the sequence:
- DIVMTQSPDSLAVSLGERATINCRASKSVSTSGYSYIYWYQQKPGQPPKLLIYLAS ILESGVPDRFSGSGSGTDFTLTISSLQAEDVAVYYCQHSRELPWTFGQGTKVEIK (SEQ ID NO:
- 2),
- wherein said bB-F5 antibody is able to activate a subset of T CD4+ cells comprising CD4+CD25+ cells.
4 more elements
Dependencies are inferred from the claim text.