Human endothelin receptor
AssigneeShionogi Seiyaku Kabushiki Kaisha
InventorsHiroo Imura, Kazuwa Nakao, Shigetada Nakanishi
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Abstract
DNA encoding an endothelin receptor shown in SEQ ID NO: 1 or 2 in the Sequence Listing is isolated from cDNA which is prepared from poly(A)+ RNA derived from a human placenta. In addition, an expression vector containing the DNA and a transformant containing the expression vector are obtained. An endothelin receptor is obtained by culturing this transformant. A receptor shown in SEQ ID NO: 1 is an ETA-receptor which has a high affinity for endothelins 1 and 2, especially for the endothelin 1. A receptor shown in SEQ ID NO: 2 is an ETB-receptor which has an affinity for endothelins 1, 2 and 3 with no selectivity.
Claims4
An isolated human endothelin receptor encoded by a polynucleotide comprising nucleotides 545 to 1765 of SEQ ID NO:
- 1.
An isolated human endothelin receptor comprising amino encoded by a polynucleotide comprising nucleotides 485 to 1765 of SEQ ID NO:
- 1.
An isolated human endothelin receptor comprising amino acid residues 21 to 427 of SEQ ID NO:
- 3.
An isolated human endothelin receptor comprising the amino acid sequence of SEQ ID NO:
- 3.
Dependencies are inferred from the claim text.