Spiro-benzo[c]chromene derivatives useful as modulators of the estrogen receptors

A compound of formula (I)

• wherein
• represents a single or double bond,
• X, Y are selected from the group consisting of O, S, SO and SO2;
• Z is selected from the group consisting of O and S;
• R1 is selected from the group consisting of hydrogen, alkyl, cycloalkyl, aryl, aralkyl, heteroaryl and heteroaryl-alkyl;
• wherein the cycloalkyl, aryl, aralkyl, heteroaryl or heteroaryl-alkyl group is optionally substituted with one or more substituents independently selected from halogen, hydroxy, alkyl, alkoxy, —SH, —S(alkyl), SO2, NO2, CN, CO2H, RC, —ORC, —SO2—NRDRE, —NRDRE, NRD—SO2—RF, -(alkyl)0-4-C(O)NRDRE, (alkyl)0-4-NRD—C(O)—RF, -(alkyl)0-4-(Q)0-1-(alkyl)0-4-NRDRE, -(alkyl)0-4-(Q)0-1-(alkyl)0-4-C(O)—ORF, -(alkyl)0-4-(Q)0-1-(alkyl)0-4-C(O)—NRDRE or -(alkyl)0-4-C(O)-(alkyl)0-4-C(O)—ORF;
• wherein RC is selected from the group consisting of alkyl, cycloalkyl, cycloalkyl-alkyl, aryl, aralkyl, heteroaryl, heteroaryl-alkyl, heterocycloalkyl and heterocycloalkyl-alkyl;
• wherein the cycloalkyl, cycloalkyl-alkyl, aryl, aralkyl, heteroaryl, heteroaryl-alkyl, heterocycloalkyl or heterocycloalkyl-alkyl group is optionally substituted with one or more substituents independently selected from halogen, hydroxy, alkyl, alkoxy, —SH, —S(alkyl), SO2, NO2, CN, CO2H, RC, —SO2—NRDRE, NRDRE, NRD—SO2—RF, -(alkyl)0-4-C(O)—NRDRE, (alkyl)0-4—NRD—C(O)—RF, -(alkyl)0-4-(Q)0-1-(alkyl)0-4-NRDRE, -(alkyl)0-4-(Q)0-1-(alkyl)0-4-C(O)—ORF, -(alkyl)0-4-(Q)0-1-(alkyl)0-4-C(O)—NRDRE or -(alkyl)0-4-C(O)-(alkyl)0-4-C(O)—ORF;
• wherein Q is selected from the group consisting of O, S, NH, N(alkyl) and —CH═CH—;
• wherein RD and RE are each independently selected from the group consisting of hydrogen and alkyl;
• alternatively RD and RE are taken together with the nitrogen atom to which they are bound to form a 4 to 8 membered ring selected from the group consisting of heteroaryl or heterocycloalkyl;
• wherein the heteroaryl or heterocycloalkyl group is optionally substituted with one or more substituents independently selected from halogen, hydroxy, alkyl, alkoxy, carboxy, amino, alkylamino, dialkylamino, nitro or cyano;
• wherein RF is selected from the group consisting of hydrogen, alkyl, cycloalkyl, cycloalkyl-alkyl, aryl, aralkyl, heteroaryl, heteroaryl-alkyl, heterocycloalkyl and heterocycloalkyl-alkyl;
• wherein the cycloalkyl, aryl, heteroaryl, heteroaryl-alkyl, heterocycloalkyl or heterocycloalkyl-alkyl group is optionally substituted with one or more substituents independently selected from halogen, hydroxy, alkyl, alkoxy, carboxy, amino, alkylamino, dialkylamino, nitro or cyano;
• R2 is selected from the group consisting of hydroxy, alkyl, cycloalkyl, aryl, aralkyl, heteroaryl and heteroaryl-alkyl;
• wherein the cycloalkyl, aryl, aralkyl, heteroaryl or heteroaryl-alkyl group is optionally substituted with one or more substituents independently selected from halogen, hydroxy, alkyl, alkoxy, —SH, —S(alkyl), SO2, NO2, CN, CO2H, RC, —ORC, —SO2—NRDRE, —NRDRE, NRD—SO2—RF, -(alkyl)0-4-C(O)NRDRE, (alkyl)0-4-NRD—C(O)—RF, -(alkyl)0-4-(Q)0-1-(alkyl)0-4-NRDRE, -(alkyl)0-4-(Q)0-1-(alkyl)0-4-C(O)—ORF, -(alkyl)0-4-(Q)0-1-(alkyl)0-4-C(O)—NRDRE or -(alkyl)0-4-C(O)-(alkyl)0-4-C(O)—ORF;
• alternatively, R1 and R2 are taken together with the carbon atom to which they are bound to form C(O);
• m is an integer selected from 0 to 4;
• R3 is independently selected from the group consisting of halogen, hydroxy, RC, amino, alkylamino, dialkylamino, nitro, cyano, SO2, —C(O)RG, —C(O)ORG, —OC(O)RG, —OC(O)ORG, —OC(O)N(RG)2, —N(RG)C(O)RG, —OSi(RG)3—ORG, —SO2N(RG)2, —O-(alkyl)1-4-C(O)RG and —O-(alkyl)1-4-C(O)ORG;
• wherein each RG is independently selected from hydrogen, alkyl, aryl, aralkyl and 1,7,7-trimethyl-2-oxabicyclo[2.2.1]heptan-3-one;
• wherein the alkyl, aryl or aralkyl group is optionally substituted with one or more substituents independently selected from alkyl, halogenated alkyl, alkoxy, halogen, hydroxy, nitro, cyano, —OC(O)-alkyl or —C(O)O-alkyl;
• alternatively two RG groups are taken together with the nitrogen atom to which they are bound to form a heterocycloalkyl group;
• wherein the heterocycloalkyl group is optionally substituted with one or more substituents independently selected from halogen, hydroxy, alkyl, alkoxy, carboxy, amino, alkylamino, dialkylamino, nitro or cyano;
• I is an integer selected from 0, 1.