Alkyne compounds with MCH antagonistic activity and medicaments comprising these compounds

An alkyne compound of formula IIa:

• wherein
• R1 and R2 together form an alkylene bridge in such a way that R1R2N— denotes a pyrrolidine group, wherein one or more H atoms are optionally replaced by R14,
• X is —CH2—CH2—O— or —CH2—CH2—NR4—, wherein one or two C atoms in each case are optionally substituted with one or two identical or different substituents selected from C1-6-alkyl,
• Z is a single bond,
• R4 is H or C1-4-alkyl,
• R14 denotes C1-4-alkyl, C2-4-alkenyl, C2-4-alkynyl, C3-7-cycloalkyl, C3-7-cycloalkyl-C1-3-alkyl, hydroxy, ω-hydroxy-C1-3-alkyl, C1-4-alkoxy, ω-(C1-4-alkoxy)-C1-3-alkyl, C1-4-alkyl-carbonyl, carboxy, C1-4-alkoxycarbonyl, hydroxy-carbonyl-C1-3-alkyl, C1-4-alkoxycarbonyl-C1-3-alkyl, C1-4-alkoxy-carbonylamino, C1-4-alkoxy-carbonylamino-C1-3-alkyl, amino, C1-4-alkyl-amino, C3-7-cycloalkyl-amino, N-(C3-7-cycloalkyl)-N-(C1-4-alkyl)-amino, di-(C1-4-alkyl)-amino, amino-C1-3-alkyl, C1-4-alkyl-amino-C1-3-alkyl, C3-7-cycloalkyl-amino-C1-3-alkyl, N-(C3-7-cycloalkyl)-N-(C1-4-alkyl)-amino-C1-3-alkyl, di-(C1-4-alkyl-amino-C1-3-alkyl, cyclo-C3-6-alkyleneimino-C1-3-alkyl, aminocarbonyl, C1-4-alkyl-amino-carbonyl, C3-7-cycloalkyl-amino-carbonyl, N-(C3-7-cycloalkyl)-N-(C1-4-alkyl)-amino-carbonyl, di-(C1-4-alkyl)-amino-carbonyl,
• Q is CH,
• L1, L2, and L3, independently of one another are F, Cl, Br, I, OH, cyano, C1-4-alkyl, C2-4-alkynyl, C1-4-alkoxy, difluoromethyl, trifluoromethyl, amino, C1-4-alkylamino, di-(C1-4-alkyl)-amino, acetylamino, aminocarbonyl, difluoromethoxy, trifluoromethoxy, amino-C1-3-alkyl, C1-4-alkylamino-C1-3-alkyl or di-(C1-4-alkyl)-amino-C1-3-alkyl or nitro, with the proviso that a phenyl may only be monosubstituted by nitro,
• m, n, and p, independently of one another represent the values 0, 1 or 2, and p may also have the value 3,
• while in the above-mentioned groups X, R1, R2, R4 and R14 one or more C atoms are optionally additionally mono- or polysubstituted by F and/or one or two C atoms, independently of one another, are optionally additionally monosubstituted by Cl or Br,
• or a tautomer, a diastereomer, an enantiomer, a mixture thereof or a salt thereof.