US 7,452,909 B2 · Imidazole derivatives

Abstract

The present invention relates to imidazole derivatives of formula I wherein R1, R2, R3, R4, X, Y and R are described hereinabove, or a pharmaceutically acceptable salt thereof. The invention also relates to a pharmaceutical composition comprising the imidazole derivatives of formula I, a process for preparing a compound of formula I, and a method of treating or preventing acute and/or chronic neurological disorder comprising administering to a patient in need of such treatment and/or prevention a therapeutically effective amount of said pharmaceutical composition. These disorders include Alzheimer's disease. These disorders also include mild cognitive impairment.

Claims3

Dependent claims

A compound of formula I

wherein
R1 is selected from halogen, lower alkyl, lower alkoxy, CF3 and cyano;
R2 is selected from the group consisting of:
pyridyl;
pyridyl substituted by lower alkyl;
and pyridyl substituted by halogen;
R3 is selected from hydrogen, C(O)H and CH2R5, wherein R5 is selected from hydrogen, OH, C1-C6-alkyl and C3-C12-cycloalkyl;
R4 is lower alkyl or C3-C12-cycloalkyl;
X is N;
Y is —(CHR)1,2 or 3;
and
R is hydrogen or lower alkyl;
or a pharmaceutically acceptable salt thereof.

10 more elements

Dependencies are inferred from the claim text.

Facts

Application

10/926,670Filed 26 Aug 2004

Priority

EP 030196044 Sep 2003

Published

US 2005/0054686 A110 Mar 2005

Granted

18 Nov 2008

Term ends

Not estimatedThe source records don’t support an estimate.

Classification26 codes

C07D 401/06
Containing two hetero rings: linked by a carbon chain containing only aliphatic carbon atoms
A61P 1/08
Drugs for disorders of the alimentary tract or the digestive system: for nausea, cinetosis or vertigo; Antiemetics
A61P 3/10
For glucose homeostasis: for hyperglycaemia, e.g. antidiabetics
A61P 9/00
Drugs for disorders of the cardiovascular system

Imidazole derivatives

Life of this patent

Imidazole derivatives

Life of this patent

Abstract

Claims3