Phenylalanine derivatives
AssigneeAjinomoto Co., Inc.
InventorsNobuyasu Suzuki, Toshihiko Yoshimura, Eiji Nakanishi, Masahiro Murata, Takashi Tsuji
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Abstract
Specific phenylalanine derivatives or pharmaceutically acceptable salts thereof have an antagonistic effect on the α 4 integrins and, therefore, are usable as therapeutic agents or preventive agents for diseases in which α 4 integrin-depending adhesion process participates in the pathology, such as inflammatory diseases, rheumatoid arthritis, inflammatory bowel diseases, systemic lupus erythematosus, multiple sclerosis, Sjögren's syndrome, asthma, psoriasis, allergy, diabetes, cardiovascular diseases, arterial sclerosis, restenosis, tumor proliferation, tumor metastasis and transplantation rejection.
Claims24
A phenylalanine compound of formula (1) or a pharmaceutically acceptable salt thereof:
- wherein A represents one of formula (26-2), (26-3), or (27):
- wherein each of Ra, Rb, Rc, and Rd represents a hydrogen atom,
- R2 and R2′ together form an alkylene group having 4 to 6 carbon atoms,
- each of R3 and R4 represents a hydrogen atom, a lower alkyl group, a lower alkoxyl group, a lower alkoxycarbonyl group, a lower alkylcarbonyl group, a cyano group, or a nitro group,
- B represents a hydroxyl group or a lower alkoxyl group,
- E represents a hydrogen atom,
- D represents a phenyl group which may be substituted with one or more substituents selected from the group consisting of halogeno, alkoxy, alkyl, hydroxyl, halogenoalkyl, halogenoalkoxy, and lower-alkylsulfonylamino,
- T represents C(═O), and
- J and J′ may be the same or different from each other and each represents a hydrogen atom, a halogen atom, a lower alkyl group, a lower alkyloxy group or nitro group.
A phenylalanine compound or pharmaceutically acceptable salt thereof, which is selected from the group consisting of the following structural formulae
- and pharmaceutically acceptable salts thereof.
Dependencies are inferred from the claim text.