Pyrimidine-sulfamides and their use as endothelian receptor antagonist

A compound of the general formula I,

• wherein
• R1 represents lower alkyl-O—(CH2)n—, cycloalkyl-O—(CH2)n—, cycloalkyl-CH2—O—(CH2)n—;
• R2 represents —CH3;
• Ra—Y—(CH2)m—;
• R3 represents aryl;
• heteroaryl;
• R4 represents hydrogen;
• trifluoromethyl;
• lower alkyl;
• lower alkyl-amino;
• lower alkyloxy;
• lower alkyloxy-lower alkyloxy;
• hydroxy-lower alkyloxy;
• lower alkyl-sulfinyl;
• lower alkylthio;
• lower alkylthio-lower alkyl;
• hydroxy-lower alkyl;
• lower alkyloxy-lower alkyl;
• hydroxy-lower alkyloxy-lower alkyl;
• hydroxy-lower alkyl-amino;
• lower alkylamino-lower alkyl;
• amino;
• di-lower alkylamino;
• [N-(hydroxy-lower alkyl)-N-(lower alkyl)]-amino;
• aryl;
• arylamino;
• aryl-lower alkylamino;
• aryl-thio;
• aryl-lower alkylthio;
• aryloxy;
• aryl-lower alkyloxy;
• aryl-lower alkyl;
• arylsulfinyl;
• heteroaryl;
• heteroaryl-oxy;
• heteroarylamino;
• heteroarylthio;
• heteroaryl-lower alkyl;
• heteroarylsulfinyl;
• heterocyclyl;
• heterocyclyl-lower alkyloxy;
• heterocyclyloxy;
• heterocyclylamino;
• heterocyclyl-lower alkylamino;
• heterocyclylthio;
• heterocyclyl-lower alkylthio;
• heterocyclyl-lower alkyl;
• heterocyclylsulfinyl;
• cycloalkyl;
• cycloalkyloxy;
• cycloalkyl-lower alkyloxy;
• cycloalkylamino;
• cycloalkyl-lower alkylamino;
• cycloalkylthio;
• cycloalkyl-lower alkylthio;
• cycloalkyl-lower alkyl;
• cycloalkylsulfinyl;
• R6 represents hydrogen or methyl;
• X represents oxygen;
• sulfur;
• —CH2— or a bond;
• Y represents a bond, —O—;
• —NH—;
• —SO2—NH—;
• —NH—SO2—NH—;
• —O—CO—;
• —CO—O—;
• —O—CO—NH—;
• —NH—CO—O—;
• —NH—CO—NH—;
• n represents the integers 2, 3, or 4;
• m represents the integers 2, 3, or 4;
• and
• Ra represents aryl, heteroaryl, lower alkyl, cycloalkyl, hydrogen;
• and optically pure enantiomers, mixtures of enantiomers, optically pure diastereomers, mixtures of diastereomers, diastereomeric racemates, mixtures of diastereomeric racemates and the meso-forms and pharmaceutically acceptable salts thereof.