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US 7,452,889 B2Granted
Substituted heterocyclic compounds
AssigneeCV Therapeutics, Inc.
InventorsElfatih Elzein, Prabha Ibrahim, Venkata Palle, Kenneth Rehder, Jeff Zablocki
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Abstract
Disclosed are novel substituted heterocyclic derivatives having the structure of Formula I: The compounds are useful for the treatment of various disease states, in particular cardiovascular diseases such as atrial and ventricular arrhythmias, intermittent claudication, Prinzmetal's (variant) angina, stable and unstable angina, exercise induced angina, congestive heart disease, diabetes, and myocardial infarction.
Claims11
A compound of Formula I:
- wherein:
- R1, R2, R3, R4, R5, R6, R7, and R8 are hydrogen;
- R9 is heteroaryl selected from the group consisting of five and six membered monocyclic having one or two heteroatoms selected from N and O optionally substituted with 1 to 3 substituents selected from alkyl and halogen substituted alkyl, and nine to twelve membered bicyclic heterocycles having one or two heteroatoms selected from N and O optionally substituted with 1 to 3 substituents selected from alkyl, halogen substituted alkyl, and oxo;
- R10 is benzothiazol-5-yl optionally substituted with alkyl;
- T is —O—;
- Q is —N>;
- X is an optionally substituted alkylene of 1-6 carbon atoms;
- Y is optionally substituted alkylene of 1-3 carbon atoms;
- and
- Z is —O—.
7 more elements
Dependencies are inferred from the claim text.