Quinoline- and isoquinoline-based compounds exhibiting ATP-utilizing enzyme inhibitory activity, and compositions, and uses thereof

A compound or Formula 1 or a

• pharmaceutically acceptable salt thereof, wherein:
• Ar is chosen from aryl, substituted aryl, heteroaryl, and substituted heteroaryl;
• A is —N— and B is —CH—, or A is —CH— and B is —N—;
• L is chosen from NR1 and O;
• R1 is chosen from H, alkyl, substituted alkyl, cycloalkyl, substituted cycloalkyl, heterocycloalkyl, and substituted heterocycloalkyl;
• X and Y are independently chosen from CH and N;
• G is chosen from a covalent bond and NR6;
• R6 is chosen from hydrogen and optionally substituted alkyl;
• and
• R is chosen from optionally substituted heterocycloalkyl,
• with the proviso that when Ar is phenyl, A is —N—, B is —CH—, L is NR1, R1 is H, X is CH,
• Y is CH, and G is a covalent bond, then R is not 4-methylpiperazin-1-yl.