Amidomethyl-substituted 1-(carboxyalkyl) cyclopentyl-carbonylamino-benzazepine-N-acetic acid compounds, process and intermediate products for their preparation and pharmaceutical compositions containing them

A method of preparing a compound corresponding to formula I:

• wherein
• R1 is hydrogen or a group forming a biolabile ester,
• R2 is ethyl,
• R3 is (—CH2)4—NH2, and
• R4 is hydrogen or a group forming a biolabile ester, or a physiologically acceptable salt thereof;
• said method comprising:
• reacting a compound corresponding to formula II:
• wherein R101 and R401, independently of each other, are each an acid-protecting group with a compound corresponding to formula III:
• wherein R2 and R3 have the above meanings, and
• if at least one of R101 and R401 is not a desired biolabile ester forming group, cleaving off such groups to release an acid group, and thereafter converting the acid group to a biolabile ester, and
• optionally converting an acid or base of Formula I into a corresponding physiologically acceptable salt, or
• optionally converting a salt of formula I into a corresponding free acid or base.