Formulations and uses of 2-hydroxy-5-phenylazobenzoic acid derivatives
AssigneeSalix Pharmaceuticals, Inc.
InventorLorin Johnson
Life of this patent
Estimating the term…
Abstract
A method of increasing the bioavailability of balsalazide by administration of an oral dosage form with food is provided, as well as an article of manufacture comprising an oral dosage form of balsalazide in a suitable container and associated with printed labeling which describes the increased bioavailability of the medication in the container when taken with food.
Claims20
A method of increasing the bioavailability of balsalazide and metabolites 5-aminosalicylic acid (5-ASA) and N-acetyl-5-ASA (NASA) comprising administering to a subject a therapeutically effective amount of a solid dosage form of balsalazide with food, wherein the solid dosage form is a tablet or capsule, wherein administering with food comprises administering the solid dosage form within 15 minutes after eating a meal, wherein the bioavailability of balsalazide, 5-ASA or NASA is increased compared to administering balsalazide without food, and wherein the method decreases the systemic adsorption of the 5-ASA and NASA metabolites.
A method of increasing the bioavailability of balsalazide and metabolites 5-aminosalicylic acid (5-ASA) and N-acetyl-5-ASA (NASA) comprising administering to a subject a therapeutically effective amount of a solid dosage form of balsalazide with food, wherein the solid dosage form is a tablet or capsule, wherein with food comprises administering the balsalazide immediately after the consumption of food, wherein the bioavailability of balsalazide, 5-ASA or NASA is increased compared to administering balsalazide without food, and wherein the method decreases the systemic adsorption of the 5-ASA and NASA metabolites.
A method for increasing the time to maximum plasma concentration (Tmax) of a metabolite of balsalazide in a subject comprising administering to the subject a solid dosage form of balsalazide with food wherein the solid dosaQe form is a tablet or capsule, wherein the Tmax of the metabolite is increased as compared to administering the solid dosage form of balsalazide without food.
Dependencies are inferred from the claim text.