NIP3 family of proteins
AssigneeUniversity of Manitoba
InventorsJonathan D. Geiger, Lorrie A. Kirshenbaum
Life of this patent
Estimating the term…
Abstract
Methods and compositions for modulating necrosis and for treating neurological and cardiovascular diseases are described. The inventors have shown that BNIP3 is involved in cell necrosis and cell death involved in cardiovascular and neurological diseases.
Claims25
A method of inhibiting cell necrosis comprising administering an effective amount of a BNIP3 mutant protein selected from the group consisting of BNIP3ΔTM, comprising amino acids 1-163 of SEQ ID NO:
- 19, and BNIP33-163, comprising amino acids 3-163 of SEQ ID NO:
- 19, to a cell or animal.
A method of suppressing or inhibiting the death of a cardiovascular cell comprising administering an effective amount of a BNIP3 mutant protein selected from the group consisting of BNIP3ΔTM, comprising amino acids 1-163 of SEQ ID NO:
- 19, and BNIP33-163, comprising amino acids 3-163 of SEQ ID NO:
- 19, to a cell or animal.
A method of inhibiting hypoxia-induced cell death comprising administering an effective amount of a BNIP3 mutant protein selected from the group consisting of BNIP3ΔTM, comprising amino acids 1-163 of SEQ ID NO:
- 19, and BN1P33-163, comprising amino acids 3-163 of SEQ ID NO:
- 19, to a cell or animal.
Dependencies are inferred from the claim text.