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AssigneeTranzyme Pharma Inc.
InventorsPierre Deslongchamps, Yves Dory, Mark Peterson, Kamel Benakli, Eric Marsault, Luc Ouellet, Mahesh Ramaseshan, Martin Vézina, Daniel Fortin, Ruoxi Lan, Shigui Li, Gérald Villeneuve, Hamid Hoveyda, Sylvie Beaubien, Graeme L Fraser
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Novel spatially-defined macrocyclic compounds containing specific conformational control elements are disclosed. Libraries of these macrocycles are then used to select one or more macrocycle species that exhibit a specific interaction with a particular biological target. In particular, compounds according to the invention are disclosed as agonists or antagonists of a mammalian motilin receptor and a mammalian ghrelin receptor.
A compound having the structure of formula II:
An antagonist of a mammalian motilin receptor having the following structure:
An agonist of a mammalian ghrelin receptor having the following structure:
A compound having a structure selected from the following:
Dependencies are inferred from the claim text.