Use of an echinocandin antifungal agent in combination with a glycopeptide antibacterial agent
AssigneeTheravance, Inc.
InventorKoné Kaniga
Life of this patent
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Abstract
This invention is directed to methods of administering an echinocandin antifungal agent in combination with a glycopeptide antibacterial agent having a substituent comprising at least about 8 carbon atoms. The invention is also directed to methods of using an echinocandin antifungal agent in combination with a specified glycopeptide antibacterial agent to treat fungal infections; and to compositions, kits and systems comprising an echinocandin antifungal agent and a specified glycopeptide antibacterial agent.
Claims9
A method for administering an echinocandin antifungal agent to a subject having a fungal infection, the method comprising:
- administering to the subject an echinocandin antifungal agent selected from caspofungin or a pharmaceutically acceptable salt thereof;
- and a glycopeptide antibacterial agent selected from telavancin or a pharmaceutically acceptable salt thereof;
- wherein the fungal infection is caused by Candida albicans, Candida parapsilosis, Candida tropicalis, Candida krusei, Candida glabrata, Aspergillus fumigatus, Aspergillus terreus, Aspergillus flavus, Pseudallescheria boydii, Geotricium candidum, or a combination thereof.
A method for treating a fungal infection in a subject, the method comprising:
- administering to the subject an antifungal amount of an echinocandin antifungal agent selected from caspofungin or a pharmaceutically acceptable salt thereof;
- and a glycopeptide antibacterial agent selected from telavancin or a pharmaceutically acceptable salt thereof;
- wherein the fungal infection is caused by Candida albicans, Candida parapsilosis, Candida tropicalis, Candida krusei, Candida glabrata, Aspergillus fumigatus, Aspergillus terreus, Aspergillus flavus, Pseudallescheria boydii, Geotricium candidum, or a combination thereof.
A method for increasing the efficacy of an echinocandin antifungal agent, the method comprising administering the echinocandin antifungal agent selected from caspofungin or a pharmaceutically acceptable salt thereof;
- to a subject in combination with a glycopeptide antibacterial agent selected from telavancin or a pharmaceutically acceptable salt thereof;
- wherein the subject has a fungal infection caused by Candida albicans, Candida parapsilosis, Candida tropicalis, Candida krusei, Candida glabrata, Aspergillus fumigatus, Aspergillus terreus, Aspergillus flavus, Pseudallescheria boydii, Geotricium candidum, or a combination thereof.
Dependencies are inferred from the claim text.