Assay
OwnerIvan Mikhailovich Petyaevinventor
Life of this patent
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Abstract
A method for determining the risk of an individual of suffering from inflammation, opportunistic infection or disruption of immunoglobulin metabolism, comprising (a) determining the level of fragmentation or modification of Fc function of immunoglobulins in a sample taken from the individual and (b) determining thereby the risk of inflammation, impaired immune response or opportunistic infection. The invention also provides the use of a trypsin inhibitor in the manufacture of a medicament for use in the treatment or prevention of a disorder associated with elevated trypsin activity which is correlated with IgG fragmentation or modification.
Claims15
A method for determining the risk of an individual of suffering from inflammation, opportunistic infection or disruption of immunoglobulin function;
- comprising:
- (a) determining the level of fragmentation of immunoglobulins, or modification of Fc function of immunoglobulins whereby the Fc region is no longer capable of being recognized, in a blood sample taken from the individual using an antibody sorbent or antibody sorbents;
- (b) comparing the level of fragmentation or modification with a blood sample taken from a healthy individual or an individual suffering from inflammation, opportunistic infection or disruption of immunoglobulin function, wherein said level of fragmentation or modification is determined using an antibody sorbent or antibody sorbents;
- and
- c) determining thereby the risk of inflammation, impaired immune response or opportunistic infection;
- wherein an increased level of fragmentation or modification in the sample from the individual whose risk of inflammation, opportunistic infection or disruption of immunoglobulin function is being determined, compared to the sample from a healthy individual is associated with an increased risk, and a substantially similar level of fragmentation or modification in the sample from the individual whose risk of inflammation, opportunistic infection or disruption of immunoglobulin function is being determined compared to the sample from an individual suffering from inflammation, opportunistic infection or disruption of immunoglobulin function is associated with an increased risk.
Dependencies are inferred from the claim text.