Transformed cell with enhanced sensitivity to antifungal compound and use thereof
AssigneeSumitomo Chemical Company, Limited
InventorHiroki Nakajima
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Abstract
The present invention provides a transformed cell in which a polynucleotide having a nucleotide sequence encoding an amino acid sequence of an osmosensing histidine kinase having no transmembrane region is introduced in a functional form into a cell deficient in at least one hybrid-sensor kinase, a method of assaying the antifungal activity of a test substance using the transformed cell, and a method of searching an antifungal compound using the method, and the like.
Claims10
A transformed cell in which a polynucleotide encoding an osmosensing histidine kinase having no transmembrane region is introduced in a functional form into a cell that is deficient in at least one hybrid-sensor kinase, wherein the cell is a budding yeast cell.
Dependencies are inferred from the claim text.