Back to results
US 7,452,673 B2Granted
Photoacid generators for the synthesis of oligo-DNA in a polymer matrix
AssigneeAffymetrix, Inc.
InventorsGlenn H. McGall, Andrea Cupoletti
Life of this patent
Estimating the term…
Abstract
Compounds represented by the following structural formulas can be used as photoacid generators: Such compounds are useful, for example, in fabricating arrays of polymers.
Claims7
A compound represented by Structural Formula (III):
- or a salt thereof, wherein:
- R8 is a substituted sulfonyl, acetyl or benzoyl group;
- R9 is —H, —COOR, a substituted alkyl group or an alkenyl or aryl group;
- R10 is —NRR′, —COOR, an alkyl or alkenyl group or a substituted alkoxy or aryl group;
- and
- R and R′ are independently —H or an alkyl, alkenyl or aryl group.
3 more elements
A method of generating acid, comprising exposing to light of an appropriate wavelength a compound represented by Structural Formula (III):
- or a salt thereof, wherein:
- R8 is a substituted sulfonyl, acetyl or benzoyl group;
- R9 is —H, —COOR, a substituted alkyl group or an alkenyl or aryl group;
- R10 is —NRR′, —COOR, an alkyl or alkenyl group or a substituted alkoxy or aryl group;
- and
- R and R′ are independently —H or an alkyl, alkenyl or aryl group.
3 more elements
A process for fabricating an array of polymers comprising:
- (a) providing a solid substrate comprising a reactive group protected by an acid labile protective group;
- (b) coating said solid substrate with a film, said film comprising a photoacid generator represented by Structural Formula (III):
- or a salt thereof, wherein:
- R8 is a substituted sulfonyl, acetyl or benzoyl group;
- R9 is —H, —COOR, a substituted alkyl group or an alkenyl or aryl group;
- R10 is —NRR′, —COOR, an alkyl or alkenyl group or a substituted alkoxy or aryl group;
- and
- R and R′ are independently —H or an alkyl, alkenyl or aryl group;
- (c) activating said photoacid generator in selected regions of said substrate by selective application of light having a predetermined wavelength to provide an acid;
- (d) exposing said reactive group having said protective group to said acid such that said protective group is removed to provide an exposed reactive group;
- (e) reacting said exposed reactive group with a monomer, wherein the monomer is coupled to said exposed reactive group;
- and
- (f) repeating the steps of coating, activating, exposing and reacting to produce the array of polymers.
10 more elements
Dependencies are inferred from the claim text.