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US 7,452,555 B2Granted
Cocrystallization
AssigneeS.S.C.I., Inc.
InventorScott L. Childs
Life of this patent
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Abstract
The present disclosure relates to novel cocrystals and novel methods for cocrystallization. In particular, the disclosure includes cocrystals comprising a salt of an active agent, such as a chloride salt of an active pharmaceutical ingredient. The present disclosure also relates to methods of preparing cocrystals and methods for screening for solid state phases.
Claims11
A method of screening for a cocrystal of a hydrochloric acid salt of an active agent, comprising the steps of:
- selecting a carboxylic acid having at least 4 carbons to coordinate via hydrogen bonding with the chloride anion of the hydrochloric acid salt of the active agent,
- preparing a solution, melt, or physical mixture of the hydrochloric acid salt of the active agent and the carboxylic acid,
- subjecting the solution or melt to a crystallization process, or the physical mixture to grinding, and
- determining whether a cocrystal of the hydrochloric acid salt of the active agent and the carboxylic acid has formed.
1 more element
Dependencies are inferred from the claim text.