Synergistic antioxidant combination of delta tocols and polyphenols
AssigneeNestec S.A.
InventorsNathalie Hasler-Nguyen, Jacob Zijlstra, John P. Troup
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Abstract
A source of δ-tocotrienol and/or-tocopherol acts synergistically with an antioxidant source comprising polyphenols, to effect suppression of LDL oxidation in serum. The combination of these two antioxidant sources has wide-ranging applications in treatment of medical conditions arising from free radical generation, including arteriosclerosis and cancer.
Claims18
A composition comprising:
- (a) a source of δ-tocol comprising greater than 2% by weight said δ-tocol;
- and
- (b) polyphenols,
- wherein a dry weight ratio of said polyphenols to said δ-tocol is in the range of 25:1 to 50:1, and said δ-tocol comprises δ-tocopherol when said polyphenols comprises citrus flavonoids, and wherein said composition is substantially free of α-tocopherol.
A composition comprising in a daily dosage:
- (a) at least 5 mg δ-tocol selected from the group consisting of δ-tocopherol, δ-tocotrienol and mixtures thereof;
- and
- (b) polyphenols,
- wherein a dry weight ratio of said polyphenols to said δ-tocol is in the range of 25:1 to 50:1 , and wherein said composition is substantially free of α-tocopherol.
A composition comprising in a daily dosage:
- (a) at least 5 mg of δ-tocol selected from the group consisting of δ-tocopherol, δ-tocotrienol and mixtures thereof;
- and
- (b) polyphenols other than citrus flavonoids,
- wherein a dry weight ratio of said polyphenols to said δ-tocol is in the range of 25:1 to 50:1, and wherein said composition is substantially free of α-tocopherol.
A kit comprising:
- (a) a source of δ-tocol preferably comprising greater than 2% by weight δ-tocol;
- and
- (b) an antioxidant source comprising polyphenols,
- for separate, sequential or simultaneous administration,
- wherein a dry weight ratio of said polyphenols to said δ-tocol is in the range of 25:1 to 50:1, wherein said δ-tocol is selected from the group consisting of δ-tocopherol, δ-tocotrienol and mixtures thereof, and wherein said kit is substantially free of α-tocopherol.
A method of treating a medical condition caused by the generation of free radicals comprising the step of administering to a person in need of such treatment an effective amount of a source of δ-tocol comprising greater than 2% by weight said δ-tocol and polyphenols, wherein a dry weight ratio of said polyphenols to said δ-tocol is in the range of 25:1 to 50:1, and said δ-tocol comprises δ-tocopherol when said polyphenols comprises citrus flavonoids, and wherein administration is substantially free of α-tocopherol.
A method of preventing spoilage in a food or beverage product comprising the step of using a composition comprising a source of δ-tocol preferably comprising greater than 2% by weight δ-tocol and an antioxidant source comprising polyphenols as a preservative wherein a dry weight ratio of said polyphenols to said δ-tocol is in the range of 25:1 to 50:1, wherein said δ-tocol is selected from the group consisting of δ-tocopherol, δ-tocotrienol and mixtures thereof, and wherein said composition is substantially free of α-tocopherol.
Dependencies are inferred from the claim text.