US 7,452,543 B2 · Conjugates of galactose-binding lectins and clostridial neurotoxins as analgesics

Abstract

A class of novel agents that are able to modify nociceptive afferent function is provided. The agents may inhibit the release of neurotransmitters from discrete populations of neurones and thereby reduce or preferably prevent the transmission of afferent pain signals from peripheral to central pain fibers. They comprise a galactose-binding lectin linked to a derivative of a clostridial neurotoxin. The derivative of the clostridial neurotoxin comprises the L-chain, or a fragment thereof, which includes the active proteolytic enzyme domain of the light (L) chain, linked to a molecule or domain with membrane translocating activity. The agents may be used in or as pharmaceuticals for the treatment of pain, particular chronic pain.

Claims8

Dependent claims

An agent for the treatment of pain, wherein the agent has been obtained in the form of a fusion protein by a method comprising expressing in a host cell a genetic construct that codes for the agent, said agent comprising:

a galactose-binding lectin;
an L-chain of a clostridial neurotoxin or a fragment thereof that cleaves vesicle and/or plasma membrane associated proteins involved in the exocytic process;
and a translocating domain of a clostridial neurotoxin H-chain that translocates the L-chain or L-chain fragment into a target cell, wherein the agent is a fusion protein.

Dependencies are inferred from the claim text.

Facts

Application

11/257,500Filed 25 Oct 2005 · continuation in part

Priority

GB 9721189.08 Oct 1997

Published

US 2006/0121056 A18 Jun 2006

Granted

18 Nov 2008

Term ends

Not estimatedThe source records don’t support an estimate.

Classification8 codes

A61K 47/6415
Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is…:…
A61P 23/00
Anaesthetics
A61P 25/04
Drugs for disorders of the nervous system: centrally acting analgesics, e.g. opioids
A61P 29/00
Non-central analgesic, antipyretic or antiinflammatory agents

Family

PCT/GB98/03001Parent of this continuation-in-part · filed 7 Oct 1998

US 2006/0121056 A1Pre-grant publication · published 8 Jun 2006

Application09/529,130Parent of this continuation-in-part

US 7,052,702 B1Parent of this continuation-in-part

US 7,452,543 B2This patent

From the US filing history. Foreign family members aren’t listed.

Conjugates of galactose-binding lectins and clostridial neurotoxins as analgesics

Life of this patent

Conjugates of galactose-binding lectins and clostridial neurotoxins as analgesics

Life of this patent

Abstract

Claims8