Methods of treating cancer by administering antibodies to CD200
AssigneeTrillium Therapeutics Inc.
InventorsReginald M. Gorczynski, David A. Clark
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Abstract
Methods and compositions for regulating immunity are disclosed. For enhancing an immune response, agents that inhibit OX-2 are administered. Such methods are useful in treating cancer. For suppressing an immune response, an OX-2 protein or a nucleic acid encoding an OX-2 protein is administered. Such methods are useful in preventing graft rejection, fetal loss, autoimmune disease, allergies and in inducing tumor cell growth.
Claims19
A method of inhibiting or reducing tumor cell growth comprising administering an effective amount of an antibody that binds and inhibits an CD200 protein to a cell or an animal in need thereof.
A method of inhibiting or reducing tumor cell growth comprising:
- screening cancer patients to identify those in which expression of CD200 is upregulated;
- and administering an antibody that binds to and inhibits CD200.
A method of treating cancer comprising:
- determining whether CD200 is upregulated in a subject afflicted with cancer;
- and administering to the subject a an antibody that binds to and inhibits CD200.
A method of treating a leukemia comprising:
- determining whether CD200 is upregulated in a subject afflicted with leukemia;
- and administering to the subject an antibody that binds to and inhibits CD200.
A method of treating cancer comprising:
- administering to a subject afflicted with cancer a therapeutic composition comprising an antibody that binds to and inhibits CD200 and that i) interferes with the interaction between CD200 and a CD200 receptor thereby inhibiting the immune suppressing effect of CD200 and ii) kills cancer cells.
A method of treating cancer comprising administering an antibody that binds to CD200 wherein a) the interaction between CD200 and its receptor is blocked and b) cancer cells expressing CD200 are killed.
A method of treating cancer comprising administering an antibody that binds CD200 wherein a) the interaction between CD200 and its receptor is blocked and b) cytotoxic T cell or NK cell activity against the cancer is enhanced.
A method of treating cancer comprising administering an antibody that binds CD200 wherein a) the interaction between CD200 and its receptor is blocked and b) T cells are attracted to the tumor cells.
A method of treating cancer comprising:
- administering to a cancer patient an antibody that (i) interferes with the interaction of CD200 and a CD200 receptor, thereby inhibiting the immune suppressing effect of CD200 and (ii) kills cancer cells through complement-mediated cellular cytotoxicity or antibody-dependent cellular cytotoxicity.
Dependencies are inferred from the claim text.