Method for forming scaffolds
AssigneeChung Yuan Christian University
InventorsJuin Yih Lai, Ming-Hau Ho, Pei Yun Kuo, Hsyue-Jen Hsieh, Tzu-Yang Hsien, Da Ming Wang, Lein Tuan Hou
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Abstract
The present invention discloses a method for forming scaffolds. This invention provides various fixation agents for different polymers or applications, and a fixation process is performed at low temperature. Moreover, the method comprises a dissolution process, a temperature adjusting process, a freezing process and a fixation process, wherein the fixation process is selected from the group of a solid-liquid exchange process, a neutralization process and a gelation process.
Claims35
A method for forming scaffolds, comprising:
- providing a polymer feed and a dissolution agent;
- utilizing said dissolution agent to dissolve said polymer feed and form a solution with a specific viscosity;
- performing a freezing process at an operation temperature to solidify said solution and form a frozen solution with a polymer-rich phase and a polymer-poor phase wherein said polymer-poor phase is to form the porous part of the scaffold and said polymer-rich phase is to form the pore wall part of the scaffold;
- providing a polymer nonsolvent and adjusting the temperature of said polymer nonsolvent to be the same as or lower than said operation temperature in said freezing process;
- and
- performing a solid-liquid exchange process to replace said dissolution agent with said polymer nonsolvent and to form scaffolds.
A method for forming scaffolds, comprising:
- providing a polymer feed and a dissolution agent;
- utilizing said dissolution agent to dissolve said polymer feed and form a first solution with a specific viscosity;
- performing a freezing process at an operation temperature to solidify said first solution and form a frozen solution with a polymer-rich phase and a polymer-poor phase wherein said polymer-poor phase is to form the porous part of the scaffold and said polymer-rich phase is to form the pore wall part of the scaffold;
- providing a fixation solution and adjusting the temperature of said fixation solution to be the same as or lower than said operation temperature in said freezing process;
- and
- performing an acid-base neutralization process to solidify said polymer-rich phase matter and to form scaffolds.
A method for forming scaffolds, comprising:
- providing a polymer feed and a dissolution agent;
- utilizing said dissolution agent to dissolve said polymer feed and form a solution with a specific viscosity;
- performing a freezing process at an operation temperature to solidify said solution and form a frozen solution with a polymer-rich phase and a polymer-poor phase wherein said polymer-poor phase is to form the porous part of the scaffold and said polymer-rich phase is to form the pore wall part of the scaffold;
- providing a crosslinking agent and adjusting the temperature of said crosslinking agent to be the same as or lower than said operation temperature in said freezing process;
- and
- performing a gelation process to utilize said crosslinking agent for gelling said polymer-rich phase matter and forming scaffolds.
Dependencies are inferred from the claim text.