System and method for analyte measurement using dose sufficiency electrodes
AssigneeRoche Diagnostics Operations, Inc.
InventorsDavid W. Burke, Nigel A. Surridge, Henning Groll
Life of this patent
Estimating the term…
Abstract
A method of measuring an analyte in a biological fluid comprises applying an excitation signal having a DC component and an AC component. The AC and DC responses are measured; a corrected DC response is determined using the AC response; and a concentration of the analyte is determined based upon the corrected DC response. Other methods and devices are disclosed.
Claims19
A method of determining dosage fill level in a test strip for performing a measurement on a biological fluid comprising:
- providing a biological fluid test strip, comprising:
- a capillary fill chamber extending a length along the test strip from an opening to a terminus, and
- at least two pairs of dose sufficiency electrodes in operative communication with the chamber, each of the pairs of dose sufficiency electrodes positioned to define a respective gap between one another;
- dosing the test strip with a biological fluid effective to cause the biological fluid to begin to fill the chamber;
- applying a test signal to at least one electrode of each of the dose sufficiency electrode pairs;
- measuring a respective response to the test signal at each of the dose sufficiency electrode pairs;
- determining the dosage fill level based upon the responses.
A method of determining a fill level of a biological fluid in a test strip for performing a measurement on the fluid comprising:
- providing a test strip, comprising:
- a fluid flow intake opening;
- a fluid flow terminus;
- at least two measurement electrodes disposed on the test strip between the opening to the terminus;
- and
- at least two pairs of dose sufficiency electrodes positioned between the measurement electrodes and the terminus, each of the pairs of dose sufficiency electrodes defining a respective gap between one another;
- introducing the biological fluid to the opening effective to cause the fluid to flow toward the terminus;
- applying a test signal to at least one electrode of each of the dose sufficiency electrode pairs;
- and
- measuring a respective response to the test signal at each of the dose sufficiency electrode pairs;
- determining the fill level of the biological fluid based upon the responses.
A method of determining dosage fill rate in a biological fluid test strip comprising:
- providing a biological fluid test strip, comprising:
- a capillary fill chamber extending a length along the test strip from an opening to a terminus,
- and at least two dose sufficiency electrodes in operative communication with the chamber, the dose sufficiency electrodes positioned to define a gap between one another;
- dosing the test strip with a biological fluid effective to cause the biological fluid to begin to fill the chamber;
- applying a test signal having an AC component to at least one of the dose sufficiency electrodes;
- measuring a first response to the test signal at a first time;
- measuring a second response to the test signal at a second time;
- and
- determining a rate at which the biological fluid fills the chamber based at least in part upon the first response and the second response.
A method of determining dosage fill rate in a biological fluid test strip comprising:
- providing a biological fluid test strip, comprising:
- a fluid flow intake opening;
- a fluid flow terminus;
- a measurement zone positioned between the opening and the terminus,
- and at least two dose sufficiency electrodes positioned between the measurement zone and the terminus, the dose sufficiency electrodes positioned to define a gap between one another;
- dosing the test strip with a biological fluid effective to cause the biological fluid to begin to flow from the opening toward the terminus;
- applying a test signal having an AC component to at least one of the dose sufficiency electrodes;
- measuring a first response to the test signal at a first time;
- measuring a second response to the test signal at a second time;
- and
- determining a rate at which the biological fluid fills the chamber based at least in part upon the first response and the second response.
Dependencies are inferred from the claim text.