Biomedical compositions
AssigneeCommonwealth Scientific and Industrial Reseach Organization
InventorsJason Watling, Justine Leigh Jeffery, Pathiraja Arachchillage Gunatillake, Timothy Charles Hughes
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Abstract
The invention provides in one form a macromonomer comprising a polysiloxane copolymer having a backbone structure derived from siloxane monomer units that are substituted or unsubstituted arylsiloxanes, arylalkylsiloxanes, alky(alkyl)siloxanes of the general formula —R1R2SiO— and wherein the terminal groups of the copolymer backbone include crosslinkable groups and wherein pendent from the backbone are at least two crosslinkable groups. The macromonomer may be cured in vivo by ultraviolet or visible light. The invention includes intraocular lenses formed by such macromonomers.
Claims15
A biomedical implant comprising a polymer that is cured from a composition comprising a random or block macromonomer of general formula:
- wherein
- L is a spacer group;
- Z is a crosslinkable group and the macromonomer contains at least one pendant Z;
- each R1 is independently C1 to C6 alkyl or perfluorinated C1 to C6 alkyl;
- each R2 is independently an R1 or L-Z group;
- the molar percentage of:
- n is from 50 up to but not including 100%;
- m is from 0 to 10%;
- o is from 0 to 50%;
- p is from 0 to 2%, and o+p=0 when L or R1 contain fluorine;
- q is from 0 to 2%;
- s is from 0 to 2%;
- the molecular weight of the macromonomer being more than 3,000;
- and
- wherein
- the macromonomer is curable in vivo and when polymerized to form the cured polymer, the polymer has a shear modulus as measured by a Micro Fourier Rheometer between 0.1 and 5 kPa.
Dependencies are inferred from the claim text.