Differentiation and identification of analogous chemical or biological substances with biosensors

A method of detecting a particular substance using a biosensor detection system, said method including:

• providing at least two biosensor devices, each biosensor device including:
• a piezoelectric material,
• an input transducer mounted on the piezoelectric material to receive an input radio frequency signal and propagate a corresponding acoustic wave within the piezoelectric material,
• an output transducer mounted on the piezoelectric material to receive the surface acoustic wave and transmit a corresponding output radio frequency signal,
• a biolayer mounted on the piezoelectric material to receive a substance to be tested and cause a corresponding change in the acoustic wave, and
• an oscillator circuit connected to the input transducer and to the output transducer, said oscillator circuit including an amplifier and producing an output signal indicative of a change in the acoustic wave,
• the biosensor devices having different biolayers which are chemically orthogonal or semi-orthogonal to each other,
• supplying a substance to be tested to the biolayers of the biosensor devices, and
• utilizing the output signals from the biosensor devices to detect receipt of the particular substance by the biolayers of the biosensor devices.