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US 7,449,458 B2Granted
Prodrugs of 2,4-pyrimidinediamine compounds and their uses
AssigneeRigel Pharmaceuticals, Inc.
InventorsSomasekhar Bhamidipati, Rajinder Singh, Valentino J. Stella, Thomas Sun
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Abstract
The present disclosure provides prodrugs of biologically active 2,4-pyrimidinediamine compounds of structural formula shown below, compositions comprising these compounds, intermediates and methods for synthesizing these compounds, and methods for using these compounds in a variety of applications including treatment of autoimmune diseases.
Claims13
A compound according to structural formula (IIIa):
- or a pharmaceutically acceptable salt wherein Rp is —CH2—O—P(O)(OH)2.
N4-(2,2-dimethyl-4-[(dihydrogen phosphonoxy)methyl]-3-oxo-5-pyrido [1,4]oxazin-6-yl)-5-fluoro-N2-(3,4,5-trimethoxyphenyl)-2,4-pyrimidinediamine disodium salt hexahydrate.
Dependencies are inferred from the claim text.