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US 7,449,180 B2Granted
Macroscopic scaffold containing amphiphilic peptides encapsulating cells
OwnerJohn Kisiday, Alan Grodzinsky +1inventors
InventorsJohn Kisiday, Alan Grodzinsky, Shuguang Zhang
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Abstract
The invention features peptide scaffolds that are useful in the repair and replacement of various tissues. The invention also provides methods for making these scaffolds and methods for using them.
Claims26
A macroscopic scaffold comprising amphiphilic peptides and living cells, wherein said peptides have alternating hydrophobic and hydrophilic amino acids comprise multiple KLD subunits, are complementary and structurally compatible, and self-assemble into a beta-sheet macroscopic scaffold;
- and wherein said macroscopic scaffold is formed by the peptides self-assembling to encapsulate the living cells, said cells being present within said macroscopic scaffold in a three-dimensional arrangement.
Dependencies are inferred from the claim text.