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US 7,448,184 B2Granted
Method for forming a laminate assembly with an ultrasonic welder
AssigneeGlaxo Group Limited
InventorsVerna Lo Clark, Michael Mary Van Oort, Richard Ian Walker
Life of this patent
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Abstract
A laminate assembly, comprising a base sheet having at least one blister formed therein, a pharmaceutical composition displaced in the blister, a lid sheet bonded to the base sheet to form a primary seal therebetween, thus forming a primarily sealed laminate assembly; the primary sealed laminate assembly having a secondary seal formed therein, and related manufacturing method and system of manufacture.
Claims25
A method for forming a laminate assembly, comprising the steps of:
- a. providing a base sheet and a lid sheet, said base sheet having formed therein a blister pocket containing a pharmaceutical composition and comprising a first mating surface;
- said lid sheet comprising a second mating surface, said base and lid sheets having a primary seal formed between said first and second mating surfaces to form a primarily sealed laminate assembly;
- b. exposing a portion of said primary sealed laminate assembly to a bonding device to create a secondary seal therein;
- wherein said bonding device is an ultrasonic welder, said ultrasonic welder comprising a welding sonotrode and an anvil, and said primary sealed laminate assembly is positioned therebetween to form said laminate structure,
- wherein said anvil comprises at least one rotary anvil defining an annular edge, and said avil comprises an axle having an axis of rotation and a pair of rotary anvils;
- a first rotary anvil having a first side extending generally tangentially from said axis of rotation and having a first annular edge;
- and a second rotary anvil having a second side extending generally tangentially from said axis of rotation and having a second annular edge;
- said first and second rotary anvils being spaced from each other, at least a portion of said first and second annular edges contacting said laminate structure during the creation of said secondary seal.
5 more elements
A method for forming a laminate assembly, comprising the steps of:
- a. providing a base sheet and a lid sheet, said base sheet having formed therein a blister pocket containing a pharmaceutical composition and comprising a first mating surface;
- said lid sheet comprising a second mating surface, said base and lid sheets having a primary seal formed between said first and second mating surfaces to form a primarily sealed laminate assembly,
- b. exposing a portion of said primary sealed laminate assembly to a bonding device to create a secondary seal therein,
- wherein said base sheet comprises a base metal layer, and said lid sheet comprises a lid metal layer, and said base and lid metal layers are at a first distance from each other in the region of said primary seal, and at a second distance from each other in the region of said secondary seal, and said first distance is greater than said second distance.
1 more element
Dependencies are inferred from the claim text.