Compositions and methods for detection of Ehrlichia canis and Ehrlichia chaffeensis antibodies
AssigneeIDEXX Laboratories, Inc.
InventorsRobert Lawton, Thomas Patrick O'Connor, Jr., Barbara Ann Bartol, Paul Scott MacHenry
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Abstract
The invention provides methods and compositions for the detection of Ehrlichia canis and Ehrlichia chaffeensis antibodies and antibody fragments.
Claims17
An isolated polypeptide consisting of the amino acid sequence of SEQ ID NO:2 or consisting of phenotypically silent amino acid substitution variants of the amino acid sequence of SEQ ID NO:2 that specifically bind to an anti-Ehrlichia antibody.
A fusion protein comprising a first polypeptide consisting of the amino acid sequence of SEQ ID NO:2 or consisting of a phenotypically silent amino acid substitution variant of the amino acid sequence of SEQ ID NO:2, wherein the first polypeptide specifically binds to an anti-Ehrlichia antibody, and a second polypeptide comprising a heterologous polypeptide.
A multimeric polypeptide comprising two or more copies of the amino acid sequence of SEQ ID NO:2 or phenotypically silent amino acid substitution variants of the amino acid sequence of SEQ ID NO:2, wherein the amino acid substitution variants specifically bind to an anti-Ehrlichia antibody.
An isolated polypeptide consisting of the amino acid sequence of SEQ ID NO:2 or an isolated variant consisting of the polypeptide having at least 90% identity to the amino acid sequence of SEQ ID NO:2, wherein the isolated polypeptide specifically binds to an anti-Ehrlichia antibody.
A fusion protein comprising a first polypeptide consisting of the amino acid sequence of SEQ ID NO:2 or an isolated variant consisting of the polypeptide having at least 90% identity to the amino acid sequence of SEQ ID NO:2, wherein the first polypeptide specifically binds to an anti-Ehrlichia antibody, and a second polypeptide comprising a heterologous polypeptide.
A multimeric polypeptide comprising two or more copies of the amino acid sequence of SEQ ID NO:2 or variants of the amino acid sequence of SEQ ID NO:2 having at least 90% identity to the amino acid sequence of SEQ ID NO:2, wherein the variants specifically bind to an anti-Ehrlichia antibody.
An isolated polypeptide consisting of the sequence of SEQ ID NO:2.
Dependencies are inferred from the claim text.