Enzymatic treatment of retinitis pigmentosis
OwnerPaola Ammannati, Roberto Giordaniinventors
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Abstract
A pharmaceutical kit for treatment of retinitis pigmentosis and a method of producing the same, the kit comprising the enzymes glutathione peroxidase, prolidase, glucose-6-phosephate dehydrogenase and, optionally, aldose reductase in aliquot parts and interactive quantities appropriate for administering the enzymes in accordance with a predetermined time sequence.
Claims8
A pharmaceutical kit for treatment of retinitis pigmentosis which comprises the enzymes glutathione peroxidase (Enzyme A), prolidase (Enzyme B), glucose-6-phosphate dehydrogenase (Enzyme C) and, optionally, aldose reductase (Enzyme D) in aliquot parts and interactive quantities appropriate for administering:
- a) Enzyme A at a concentration generally within a range of 0.03 U.I. and 0.05 U.I. in about 0.4 ml of physiological solution for approximately three consecutive days, at monthly intervals, for about three months and for each eye;
- b) Enzyme B, starting from the month following the last administration of Enzyme A, at a concentration generally within a range of 5 U.I. and 7 U.I. in about 0.4 ml of physiological solution for approximately three consecutive days, at monthly intervals, for about three months and for each eye;
- c) Enzyme C, starting from the month following the last administration of Enzyme B, at a concentration generally within a range of 7 U.I. and 9 U.I. in about 0.4 ml of physiological solution for approximately three consecutive days, at monthly intervals, for about three months and for each eye;
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- d) Enzyme D, starting from the month following the last administration of Enzyme C, at a concentration generally within a range of 7 U.I. and 9 U.I. in about 0.4 ml of physiological solution for approximately three consecutive days, at monthly intervals, for about three months and for each eye.
A method of producing a pharmaceutical kit which includes the enzymes glutathione peroxidase (Enzyme A), prolidase (Enzyme B), glucose-6-phosphate dehydrogenase (Enzyme C) and, optionally, aldose reductase (Enzyme D) for treatment of retinitis pigmentosis by injection into a patient's retrobulbar tissue, the method comprising the steps of providing the enzymes in aliquot parts and in interactive quantities appropriate for administering:
- a) Enzyme A at a concentration generally within a range of 0.03 U.I. and 0.05 U.I. in about 0.4 ml of physiological solution for approximately three consecutive days, at monthly intervals, for about three months and for each eye;
- b) Enzyme B, starting from the month following the last administration of Enzyme A, at a concentration generally within a range of 5 U.I. and 7 U.I. in about 0.4 ml of physiological solution for approximately three consecutive days, at monthly intervals, for about three months and for each eye;
- c) Enzyme C, starting from the month following the last administration of Enzyme B, at a concentration generally within a range of 7 U.I. and 9 U.I. in about 0.4 ml of physiological solution for approximately three consecutive days, at monthly intervals, for about three months and for each eye;
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- d) Enzyme D, starting from the month following the last administration of Enzyme C, at a concentration generally within a range of 7 U.I. and 9 U.I. in about 0.4 ml of physiological solution for approximately three consecutive days, at monthly intervals, for about three months and for each eye.
Dependencies are inferred from the claim text.