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US 7,444,273 B1Granted
Crystallization of aurora/LPL1P-related kinase
AssigneeTakeda San Diego, Inc.
InventorsCiaran N. Cronin, Mark W. Knuth, Duncan E. McRee, Jacek Nowakowski, Nikola P. Pavletich, Devon A. Thompson, Robert A. Wijnands
Life of this patent
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Abstract
Provided are crystals relating to Aurora/LPL1P-related kinase and its various uses.
Claims12
A composition comprising a protein in crystalline form wherein the protein consists of residues 24-295 of SEQ ID NO:
- 3, wherein said protein is in complex with a ligand that is bound to the ATP binding site of the protein, and wherein the protein crystal has a crystal lattice in a P6122 space group and unit cell dimensions, +/−2%, of a=80.45 Å, b=80.45 Å and c=172.18 Å.
A method for forming a crystal of a protein comprising:
- forming a crystallization volume comprising a precipitant solution and a protein that consists of residues 24-295 of SEQ ID NO:3;
- storing the crystallization volume under conditions suitable for crystal formation of the protein;
- and
- forming a protein crystal, wherein said protein is in complex with an ATP binding site ligand and wherein the protein crystal has a crystal lattice in a P6122 space group and unit cell dimensions, +/−2%, of a=80.45 Å, b=80.45 Å and c=172.18 Å.
1 more element
A noncrystalline protein consisting of SEQ ID NO:3.
A non-crystalline protein consisting of residues 24-295 of SEQ ID NO:3.
An isolated noncrystalline protein consisting of residues 24-295 of SEQ ID NO:3.
An isolated noncrystalline protein consisting of SEQ ID NO:3.
Dependencies are inferred from the claim text.