Polymorphic forms of sertraline hydrochloride
AssigneeCiba Specialty Chemicals Corporation
InventorsPaul Adriaan Van Der Schaaf, Franz Schwarzenbach, Hans Jürg Kirner, Martin Szelagiewicz, Claudia Marcolli, Andreas Burkhard
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Abstract
Sertraline hydrochloride polymorphic form II is conveniently prepared by adding hydrogen chloride to solution of sertraline free amine in a ketone. In preferred processes, the solution of sertraline free amine seeded with some crystals of polymorphic form II and/or the solution is heated before addition of the hydrogen chloride.
Claims9
A process for the preparation of sertraline hydrochloride polymorphic form II, wherein hydrogen chloride is added to a solution of sertraline free amine in a ketone selected from the group consisting of acetone, methyl ethyl ketone, and methyl isobutyl ketone wherein sertraline hydrochloride polymorphic form II is crystallized out of said solution.
Dependencies are inferred from the claim text.