Proteasome inhibitors
AssigneeMillenium Pharmaceuticals, Inc.
InventorsEdward J. Olhava, Mihaela Diana Danca
Life of this patent
Estimating the term…
Abstract
The present invention provides novel compounds useful as proteasome inhibitors. The invention also provides pharmaceutical compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various diseases.
Claims10
A compound of formula (I):
- or a pharmaceutically acceptable salt or boronic acid anhydride thereof, wherein:
- Z1 and Z2 are each independently hydroxy, alkoxy, aryloxy, or aralkoxy;
- or Z1 and Z2 together form a moiety derived from a boronic acid completing agent;
- and
- Ring A is selected from the group consisting of
The compound [(1R)-1({[(2,4-dichlorobenzoyl)amino]acetyl{-amino)-3-methylbutyl]boronic acid or a pharmaceutically acceptable salt or boronic acid anhydride thereof.
The compound [(1R)-1-({[(2,3-dichlorobenzoyl)amino]acetyl{-amino)-3-methylbutyl]boronic acid or a pharmaceutically acceptable salt or boronic acid anhydride thereof.
The compound [(1R)-1-({[(2,5-dichlorobenzoyl)amino]acetyl{-amino)-3-methylbutyl]boronic acid or a pharmaceutically acceptable salt or boronic acid anhydride thereof.
The compound [(1R)-1-({[(4-chloro-2-fluorobenzoyl)amino]-acetyl{amino)-3-methylbutyl]boronic acid or a pharmaceutically acceptable salt or boronic acid anhydride thereof.
The compound [(1R)-1-({[(5-chloro-2-fluorobenzoyl)amino]acetyl{-amino)-3-methylbutyl]boronic acid or a pharmaceutically acceptable salt or boronic acid anhydride thereof.
Dependencies are inferred from the claim text.