Process for producing dioxolane nucleoside analogues
AssigneeShire BioChem Inc.
InventorsGregory Bydlinski, Qing Yu, Alex Cimpoia
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Abstract
The present invention relates to a process conducted in a single reaction vessel for producing a dioxolane nucleoside analogue of formula I or a pharmaceutically acceptable salt thereof; the process comprising the steps of adding a Lewis acid, a silylating agent and a non-silylated purine or pyrimidine base or an analogue thereof to a dioxolane of formula II. The invention also provides a process for producing a dioxolane compound of formula III; by reacting a dioxolane compound of formula IV in a suitable solvent in the presence of DIB and I2, using a suitable source of energy.
Claims26
A process for producing a dioxolane compound of formula III
- said process comprising:
- reacting a dioxolane compound of formula IV in a solvent;
- in the presence of diacetoxy iodobenzene and I2, wherein said process is conducted using a source of energy;
- and wherein R10 is a hydroxyl protecting group.
A process for producing a dioxolane compound of formula III:
- said process comprising:
- reacting a dioxolane compound of formula IV in a solvent in the presence of diacetoxy iodobenzene and I2;
- wherein R10 is acetyl, pivaloyl, benzoyl, benzyl, or isopropyloxycarbonyl, and
- said dioxolane compound of formula IV is added to a mixture of diacetoxy iodobenzene and I2, and said process is conducted using a source of energy.
A process for producing a dioxolane compound of formula III:
- said process comprising:
- reacting a dioxolane compound of formula IV in a solvent in the presence of diacetoxy iodobenzene and I2;
- wherein
- the dioxolane compound of formula IV is added to a mixture of diacetoxy iodobenzene, I2 and acetic acid,
- R10 is acetyl, pivaloyl, benzoyl, benzyl, or isopropyloxycarbonyl;
- and
- said process is conducted using a source of energy.
Dependencies are inferred from the claim text.