Autoinducer molecules and uses therefor
AssigneesUniversity of Iowa Research Foundation, University of Rochester, East Carolina University
InventorsEverett C. Pesci, Barbara H. Iglewski, Jared B. J. Milbank, James P. Pearson, Andrew S. Kende, Everett P. Greenberg
Life of this patent
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Abstract
Novel bacterial quinolone signal molecules and, more particularly, pseudomonas quinolone signal (“PQS”) molecules, e.g., 2-heptyl-3-hydroxy-4-quinolone, and analogs and derivatives thereof are described. Therapeutic compositions containing the molecules, and therapeutic methods, methods of for regulating gene expression, methods for identifying modulators of the autoinducer molecules, and methods of modulating quorum sensing signaling in bacteria using the compounds of the invention are also described.
Claims18
A compound of formula I
- wherein:
- R1-R4 are independently H, alkyl, alkenyl, alkynyl, OH, NH2, SH, O—R6, N—R7R8, -or a halogen;
- R5 is SH, OH, O—R6, or N—R7R8;
- R6 is H or C1-C4 alkyl;
- R7 and R8 are independently H or C1-C4 alkyl;
- X is S,O, or N—R9;
- Y is N—R9;
- R9 is H or C1-C4 alkyl;
- Q has formula IA
- wherein:
- R10-R13 are independently H, C1-C4 alkyl, OH, NH2, SH, O—R25, N—R26R27, or a halogen, or R10 and R11 taken together form a carbonyl, a sulfonyl or an imino moiety, or R12 and R13 taken together form a carbonyl, a sulfonyl or an imino moiety;
- R14-R24 are independently H, C1-C4 alkyl, OH, NH2, SH, O—R25, N—R26R27, or a halogen;
- R25 is H or C1-C4 alkyl;
- and
- R26 and R27 are independently H, C1-C4 alkyl, O, or S;
- and
- salts thereof.
A compound comprising the formula:
Dependencies are inferred from the claim text.