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US 7,442,795 B2Granted
Triazole compounds useful in therapy
AssigneePfizer Inc.
InventorsJustin Stephen Bryans, Patrick Stephen Johnson, Thomas Ryckmans, Alan Stobie
Life of this patent
Estimating the term…
Abstract
A compound of formula (I), or a pharmaceutically acceptable derivative, wherein A, B, V, W, X, Y, and Z are as defined herein; pharmaceutical compositions thereof; and uses thereof.
Claims2
A compound of formula (II) or a pharmaceutically acceptable salt thereof:
- wherein:
- W is —O—, —S(O)a—, or —N(R1)—
- R1 is H, C1-6 alkyl, (CH2)bCOR2, CO(CH2)bNR2R3, SO2R2, (CH2)cOR2, (CH2)cNR2R3, or (CH2)bhet1;
- het1 is a saturated or unsaturated heterocycle of from 3 to 8 atoms containing one to four heteroatoms selected from O, N, or S, optionally substituted with C1-6 alkyl;
- X and Y are each independently H, C1-6 alkyl, halogen, OH, CF3, OCF3, or OR4;
- Ring A is a 4-7 membered, saturated N-containing heterocycle, optionally substituted with OH, and in which optionally at least one ring N is substituted with O;
- Ring B is phenyl or a 4-7 membered unsaturated N-containing heterocycle, optionally substituted with OH, halogen, CN, CONH2, CF3, or OCF3, and in which optionally at least one ring N is substituted with O;
- R2 and R3 are each independently H, C1-6 alkyl, C1-6 alkyloxy, N(C1-6 alkyl)2, or C3-8 cycloalkyl;
- wherein said C1-6 alkyl is optionally substituted with OH, halogen, N(C1-6 alkyl)2, or C1-6 alkyloxy;
- or R2 and R3 are taken together with the nitrogen atom to which they are attached to form a heterocycle of from 3 to 8 atoms, optionally substituted with C1-6 alkyl;
- R4 is C1-6 alkyl;
- a, n and c are each independently 0, 1, or 2;
- and
- b is 0 or 1.
11 more elements
Dependencies are inferred from the claim text.