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US 7,442,793 B2Granted
Peptide deformylase inhibitors
AssigneeSmithKline Beecham Corporation
InventorsJinhwa Lee, Siegfried B. Christensen, IV
Life of this patent
Estimating the term…
Abstract
Novel PDF inhibitors and novel methods for their use are provided.
Claims5
A compound according to Formula (1):
- wherein:
- R is selected from the group consisting of:
- C2-6 alkyl (optionally substituted by alkoxy, halogen, or C1-3 alkylsulfanyl);
- (CH2)n —C3-6 carbocycle (optionally substituted by alkoxy, halogen, or C1-3 alkylsulfanyl);
- and (CH2)n—R2, wherein R2 is selected from the group consisting of phenyl, furan, benzofuran, thiophene, benzothiophene, tetrahydrofuran, tetrahydropyran, dioxane, 1,4-benzodioxane or benzo[1,3]dioxole;
- R2 is optionally substituted by one or more substituent selected from Cl, Br, I, C1-3 alkyl (optionally substituted by one to three F) and C1-2 alkoxy (optionally substituted by one to three F)};
- R1 is selected from the group consisting of aryl and heteroaryl;
- Y represents CH2 or a covalent bond;
- and
- n is an integer from 0 to 2;
- or a pharmaceutically acceptable salt thereof.
8 more elements
A compound selected from the group consisting of:
- Quinoline-8-carboxylic acid ((R)-2-[(formyl-hydroxy-amino)-methyl]-heptanoylamino}-methyl)-amide;
- 1,2,3,4-Tetrahydro-quinoline-8-carboxylic acid ({(R)-2-[(formyl-hydroxy-amino)-methyl]-heptanoylamino}-methyl)-amide;
- Benzofuran-2-carboxylic acid ({(R)-2-[(formyl-hydroxy-amino)-methyl]-heptanoylamino}-methyl)-amide;
- Quinoline-6-carboxylic acid ({(R)-2-[(formyl-hydroxy-amino)-methyl]-heptanoylamino}-methyl)-amide;
- 1,2,3,4-Tetrahydro-quinoline-6-carboxylic acid ({(R)-2-[(formyl-hydroxy-amino)-methyl]-heptanoylamino}-methyl)-amide;
- 2,3-Dihydro-benzo[1,4]dioxine-6-carboxylic acid ({(R)-2-[(formyl-hydroxy-amino)-methyl]-heptanoyl]amino}-methyl)-amide;
- 7-Methoxy-benzofuran-2-carboxylic acid ({(R)-2-[(formyl-hydroxy-amino)-methyl]-heptanoylamino}-methyl)-amide;
- 5-Methoxy-benzofuran-2-carboxylic acid ({(R)-2-[(formyl-hydroxy-amino)-methyl]-heptanoylamino}-methyl)-amide;
- 3,4-Dihydro-2H-benzo[b][1,4]dioxepine-7-carboxylic acid ({(R)-2-[(formyl-hydroxy-amino)-methyl]-heptanoylamino}-methyl)-amide;
- 5-Trifluoromethyl-furan-2-carboxylic acid ({(R)-2-[(formyl-hydroxy-amino)-methyl]-heptanoylamino}-methyl)-amide;
- 3,4-Difluoro-N-({(R)-2-[(formyl-hydroxy-amino)-methyl]-heptanoylamino}-methyl )-benzamide;
- 2,3-Difluoro-N-({(R)-2-[(formyl-hydroxy-amino)-methyl]-heptanoylamino}-methyl )-benzamide;
- [1,8]Naphthyridine-2-carboxylic acid ({(R)-2-[(formyl-hydroxy-amino)-methyl]-heptanoylamino}-methyl)-amide;
- 3-Methyl-benzofuran-2-carboxylic acid ({(R)-2-[(formyl-hydroxy-amino)-methyl]-heptanoylamino}-methyl)-amide;
- Benzo[1,3]dioxole-5-carboxylic acid ({(R)-2-[(formyl-hydroxy-amino)-methyl]-heptanoylamino}-methyl)-amide;
- Benzofuran-2-carboxylic acid {[(R)-2-cyclopentylmethyl-3-(formyl-hydroxy-amino)-propanoylamino]-methyl}-amide;
- and
- Benzofuran-2-carboxylic acid ({(R)-7,7,7-trifiuoro-2-[(formyl-hydroxy-amino)-methyl]-heptanoylamino}-methyl)-amide;
- or a pharmaceutically acceptable salt thereof.
16 more elements
Dependencies are inferred from the claim text.